Kim, Sun-Ok,Kim, Sang-Hee,Cho, Eun-Ah,In, Chang-Hoon
申请号:
AU2011353283
公开号:
AU2011353283A1
申请日:
2011.12.29
申请国别(地区):
AU
年份:
2013
代理人:
摘要:
Disclosed are small interfering RNA (siRNA) that complementarily binds to a base sequence of Hif1α mRNA transcript, thereby inhibiting expression of Hif1α without inducing immune responses, and a use of the siRNA for prevention and/or treatment of cancer. Since Hif1α is commonly overexpressed in almost all cancer cells, the siRNA that complementarily binds to Hif1α-encoding mRNA may inhibit expression of Hif1α through RNA-mediated interference (RNAi), thereby inhibiting proliferation and metastasis of cancer cells, and thus, the siRNA may be useful as an anticancer agent.