Общество с ограниченной ответственностью "НооГен" (RU)
发明人:
Купрюшкин Максим Сергеевич (RU),Стеценко Дмитрий Александрович (RU)
申请号：
RU2014134383
公开号：
RU2014134383A
申请日:
2014.08.22
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
Compound 1, comprising a modified phosphate group represented by formula (I) (I) in kotoromzamestitel Z is selected from -O, -S, -Se, -BH or -N (R), where Rest H, Ci ^ alkyl or a protecting group the substituent X is selected from the group consisting of 5-end nucleoside, nucleoside analog, an oligonucleotide, modified oligonucleotide or oligonucleotide analog substituent Y is selected from the group consisting of 3-end nucleoside, nucleoside analog, an oligonucleotide, modified oligonucleotide or oligonucleotide analog -H, -OH, -SH, -NHR, -O-PG or S-PG, where PG is a protecting group linker monophosphate group or a diphosphate group, or a label or a quencher of fluorescence Y ilizamestitel selected from the group consisting of 3-end nucleoside, nucleoside analog, an oligonucleotide, modified oligonucleotide or oligonucleotide analog substituent X is selected from the group consisting of 5-end nucleoside, nucleoside analog, an oligonucleotide, modified oligonucleotide or oligonucleotide analog -H, -OH, -SH, -NHR, -O-PG or S-PG, where PG is a protecting group linker monophosphate group or a diphosphate group, or a label or a quencher of fluorescence, the substituents R, r and are independently selected from the group consisting of -H, -NRR, -OR, -SR, -S (O) R, -S (O) R , -S (O) NH, -S (O) NHR, -S (O) NR, -Calkil, -Calkenil, -Calkinil, -Caril or -Cgeteroaril wherein each of R, R, R, r and are independently selected from the group consisting of: -H, -Calkil, -Calkenil, -Calkinil, -Caril or -Cgeteroaril wherein r and additionally together form an alkylene or heteroalkylene chain length of 2-4 atoms further wherein r and together with the atoms to which they are attached, form a 5-8-membered n erotsikl further wherein r and together with the atoms to which they are attached, form a 5-8 membered heterocycle wherein each alkyl, alkenyl, alkynyl, Ari1 Соединение, содержащее модифицированную фосфатную группу, отвечающую формуле (I)(I)в которомзаместитель Z выбирается из
