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Substituted 6-(4-hydroxy-phenyl)-1H-pyrazolo[3,4-b]pyridine derivatives as kinase inhibitors
专利权人:
SANOFI
发明人:
Stephanie Hachtel,Christian Schoenau,Matthias Loehn,Oliver Plettenburg,Stefania Pfeiffer-Marek,Alexander Schiffer,Holger Gaul,Aimo Kannt,Juergen Dedio,Angela Dudda
申请号:
US14537034
公开号:
US09133181B2
申请日:
2014.11.10
申请国别(地区):
US
年份:
2015
代理人:
摘要:
The present invention relates to pyrazolo[3,4-b]pyridine compounds of the formula I,in which R1, R2, R3, R4, R5 and R6 are defined as indicated below. The compounds of the formula I are kinase inhibitors, and are useful for the treatment of diseases associated with diabetes and diabetic complications, such as, diabetic nephropathy, diabetic neuropathy and diabetic retinopathy, for example. The invention furthermore relates to the use of compounds of the formula I, in particular as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them.
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