Jay A. Berzofsky,Yi-Hsiang Huang,Masaki Terabe,Ira H. Pastan
申请号:
US13610421
公开号:
US20130039936A1
申请日:
2012.09.11
申请国别(地区):
US
年份:
2013
代理人:
摘要:
POTE has recently been identified as a tumor antigen expressed in a variety of human cancers, including colon, ovarian, breast, prostate, lung and pancreatic cancer. Described herein are immunogenic POTE polypeptides, including modified POTE polypeptides, that bind MHC class I molecules. The immunogenic POTE polypeptides are capable of inducing an immune response against POTE-expressing tumor cells. Thus, provided herein is a method of eliciting an immune response in a subject, such as a subject having a type of cancer that expresses POTE.