RADIOPAQUE NON BIODEGRADABLE WATER INSOLUBLE IODINATED BENZYL ETHERS OF POLY (VINYL ALCOHOL) PREPARATION METHOD THEREOF INJECTABLE EMBOLIZING COMPOSITIONS CONTAINING THEREOF AND USE THEREOF
CHEVALIER YVES,AGUSTI Géraldine,NYFFENEGGER CORALIE,DOELKER ERIC,JORDAN OLIVIER,ANDERSEN GERT
申请号：
IN6125/CHENP/2012
公开号：
IN2012CN06125A
申请日:
2012.07.12
申请国别(地区):
IN
年份:
2014
代理人:
摘要：
The invention concerns a radiopaque non biodegradabie water insoluble iodinated benzyl ether of polyvinyl alcohol) consisting of a PVA having covalentiy grafted thereon iodinated benzyl groups comprising 1 4 iodine atoms per benzyl group a process for preparing the same comprising reacting a 0 100 % hydrolyzed PVA with a iodinated benzyl derivative comprising 1 4 iodine atoms per benzyl group in a polar aprotic solvent in the presence of a base in anhydrous conditions. Said iodo benzylether PVA is particularly useful as embolic agent in an injectable embolizing composition. The invention also concerns an injectable embolizing composition comprising said iodo benzylether PVA and capable of forming a cohesive mass upon contact with a body fluid by precipitation of the iodo benzylether PVA. Said injectable embolizing composition is particularly useful for forming in situ a cohesive mass in a blood vessel or into a tumor. The invention further concerns a coating composition containing said iodo benzylether PVA and capable of forming a radiopaque coating on a medical device. The invention further concerns particles formed of said iodo benzylether PVA.
