PROCESSES FOR THE PREPARATION OF A 14- HYDROXINORMORPHINONE DERIVATIVE AND FOR THE PRODUCTION OF NOROXYMORPHONE

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专利权人:

发明人:

JOANNES THEODORUS MARIA LINDERS,PIETER VRIJHOF

申请号：

BR0211899

公开号：

BR0211899B1

申请日:

2002.08.15

申请国别(地区):

BR

年份:

2014

代理人:

摘要：

The present invention relates to process for the preparation of a 14-hydroxynormorphinone derivative of formula IV comprising reacting the compound of formula III, with a cobalt (II) oxidant in the presence of a mild base and air or oxygen as the cooxidant； wherein R<；SUB>；1 <；/SUB>；is (1C-7C)alkyl optionally substituted with one or more chlorines, butenyl, vinyl, benzyl, phenyl or naphthyl； and R<；SUB>；2 <；/SUB>；is benzyl or benzyl substituted with one or more (1C-6C)alkoxy group or benzyl substituted with one or more halogen. The process is very suitable in the production of noroxymorphone.

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