The present invention relates to lyophilized compositions comprising cidofovir hydroxypropyl methylcellulose (HPMC) or hydroxyethylcellulose (HEC) and optionally a plasticizer. In particular the present invention relates to such compositions which form a sheet shaped porous solid matrix. The invention also relates to methods for producing such compositions. The invention further relates to such compositions for use in treating human papillomavirus (HPV) infections and HPV associated malignancies in particular HPV lesions and cervical cancer.
