A system for estimating fractional flow reserve (FFR) includes a front end application to receive image frames from an imaging system to develop a model of a vasculature system based on an observed concentration time profile at locations within the model using contrast dye in the vasculature system and movement of the vasculature system. A graphics processing unit is configured to represent a computed concentration time profile in the vasculature system using a Lattice-Boltzmann Method (LBM) to generate a representation of the vasculature system. A dynamic controller tunes a velocity field based on a mismatch between the observed concentration time profile and the computed concentration time profile at the locations within the model to obtain a best estimate of the velocity field to perform a FFR measurement.
