The present invention relates to novel 3-phenyl-3-methoxy-pyrrolidinederivatives, useful for modulating extracellularlevels of catecholamines, dopamine and norepinephrine, in cerebral corticalareas of the mammalian brain, and more specificallyfor the treatment of central nervous system disorders. In other aspects theinvention relates to pharmaceutical compositionscomprising the 3-phenyl-3-methoxy-pyrrolidine derivatives of the invention andto the use of these compounds for therapeutic applications.