Butler, Thomas,Cho, Aesop,Kim, Choung,Saunders, Oliver,Zhang, Lijun,Parrish, Jay
申请号：
ES15155479
公开号：
ES2665272T3
申请日:
2009.04.22
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of Formula III: ** (See formula) ** or a pharmaceutically acceptable salt thereof； wherein: R1 is H or CH3； R2 is OH； R3 is H； R4 is OH； R5 is H； R6 is CN； R7 is H, or ** (See formula) ** each of Y or Y1 is, independently, O, S, NR, + N (O) (R), N (OR), + N (O) (OR ) or N-NR2； W1 and W2, when taken together, are -Y3 (C (Ry) 2) 3Y3-； or one of W1 or W2 together with R3 or R4 is -Y3- and the other of W1 or W2 is Formula Ia； or W1 and W2 are each, independently, a group of Formula Ia: ** (See formula) ** in which: each Y2 is independently a bond, O, CR2, NR, + N (O) (R) , N (OR), + N (O) (OR), N-NR2, S, SS, S (O) or S (O) 2； each Y3 is independently O, S or NR； M2 is 0, 1 or 2； each Rx is independently Ry or the formula: ** (See formula) ** in which: each M1 a, M1c and M1d is independently 0 or 1； M12c e 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 or 12； each Ry is independently H, F, Cl, Br, I, OH, R, -C (>； = Y1) R, -C (>； = Y1) OR, -C (>； = Y1) N (R) 2, - N (R) 2, - + N (R) 3, -SR, -S (O) R, -S (O) 2R, -S (O) (OR), -S (O) 2 (OR), -OC (>； = Y1) R, -OC (>； = Y1) OR, -OC (>； = Y1) (N (R) 2), -SC (>； = Y1) R, -SC (>； = Y1) OR , -SC (>； = Y1) (N (R) 2), -N (R) C (>； = Y1) R, -N (R) C (>； = Y1) OR, -N (R) C (>； = Y1) N (R) 2, -SO2NR2, -CN, -N3, -NO2, -OR or W3； or when taken together, two Ry on the same carbon atom form a carbocyclic ring of 3 to 7 carbon atoms； each R is independently H, (C1-C8) alkyl, substituted (C1-C8) alkyl, (C2-C8) alkenyl, substituted (C1-C8) alkenyl, (C1-C8) alkynyl, substituted (C1-C8) alkynyl , C6-C20 aryl, substituted C6-C20 aryl, C2-C20 heterocyclyl, substituted C2-C20 heterocyclyl, substituted arylalkyl or arylalkyl； W3 is W4 or W5； W4 is R, -C (Y1) Ry, -C (Y1) W5, -SO2Ry or -SO2W5； and W5 is a carbocycle or a heterocycle wherein W5 is independently substituted with 0 to 3 Ry groups； R8 is NR11R12； each R9 or R10 is independently H； Each R11 or R12 is independently H.Un compuesto de Fórmula III: **(Ver fórmula)** o
