Bennett, Mark K.,Gross, Matthew I.,Bromley, Susan D.,Li, Jim,Chen, Lijing,Goyal, Bindu,Laidig, Guy,Stanton, Timothy Friend,Sjogren, Eric Brian
申请号：
AU2013356241
公开号：
AU2013356241A1
申请日:
2013.12.03
申请国别(地区):
AU
年份:
2015
代理人:
摘要：
The invention relates to novel heterocyclic compounds and pharmaceutical preparations thereof and the methods of treating or preventing cancer using the compounds of the invention. Other aspects relate to methods of identifying a cancer patient that may benefit from treatment with a glutaminase inhibitor comprising determining the ratio of glutamate to glutamine, the ratio of glutaminase enzyme to glutamine synthetase or glutaminase activity in cancer cells of the patient.
