The present disclosure relates to a method and system for registering multi-modality images. The method may include: acquiring a first image relating to a registration model, wherein the registration model includes a plurality of reference objects； acquiring a second image relating to the registration model； determining a set of reference points based on the plurality of reference objects； determining a set of mapping data corresponding to the set of reference points in the first image and the second image； and determining one or more registration parameters based on the set of mapping data.
