In vivo and ex vivo expansion of hematopoietic stem cells with a targeted combination of clinically tested, FDA approved drugs

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专利权人:

Peter S. Klein;Jian Huang

发明人:

Peter S. Klein,Jian Huang

申请号：

US13084180

公开号：

US09050315B2

申请日:

2011.04.11

申请国别(地区):

US

年份:

2015

代理人:

摘要：

The present invention provides a therapeutic approach to maintain and expand HSCs in vivo using currently available medications that target GSK-3 and mTOR. The present invention also provides a system and method for the ex vivo culturing of HSCs, where an mTOR inhibitor is combined with a GSK-3 inhibitor within the culturing conditions.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/