The present invention relates to anti-factor D antibody variants, the production of those variants, and their variations in the preparation of compositions and medicaments for the treatment of diseases and disorders associated with over-complement activation or uncontrolled complement activation. Regarding the use of the body. [Selection] Figure 1B本発明は抗D因子抗体変異体、それらの変異体の作製、及び過剰補体活性化または無制御補体活性化に関連する疾患及び障害の治療用の組成物及び医薬の調製におけるそれらの変異体の使用に関する。【選択図】図1B