Az ALAS1 gén expressziójának gátlására szolgáló készítmények és eljárások

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专利权人:

Alnylam Pharmaceuticals, Inc.;Icahn School of Medicine at Mount Sinai

发明人:

BETTENCOURT, Brian,FITZGERALD, Kevin,QUERBES, William,DESNICK, Robert,YASUDA, Makiko

申请号：

HUE14800179

公开号：

HUE049227T2

申请日:

2014.10.03

申请国别(地区):

HU

年份:

2020

代理人:

摘要：

The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting expression of ALAS1, wherein said dsRNA comprises a sense strand and an antisense strand, the antisense strand comprising a region of complementarity to an ALAS1 RNA transcript, which antisense strand comprises at least 22 contiguous nucleotides from the antisense sequence of UAAGAUGAGACACUCUUUCUGGU (SEQ ID NO: 4153) or UAAGAUGAGACACUCTUUCUGGU (SEQ ID NO: 4154).

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/