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2-IMMEDAZOES REPLACED AS RECEPTOR MODULATORS ASSOCIATED WITH AMINE TRACES
专利权人:
F. HOFFMANN-LA ROCHE AG
发明人:
GUIDO GALLEY,KATRIN GROEBKE ZBINDEN,ROGER NORCROSS,HENRI STALDER
申请号:
BRPI0718054
公开号:
BRPI0718054A2
申请日:
2007.10.23
申请国别(地区):
BR
年份:
2013
代理人:
摘要:
The present invention relates to compounds of formula I wherein R1 is selected from the group consisting of hydrogen and lower alkyl; each R2 is independently selected from the group consisting of hydrogen and lower alkyl; each R3 is independently selected from the group consisting of hydrogen, lower alkyl, lower alkoxy, phenyloxy, benzyloxy, halogen and lower alkyl substituted by halogen; X is selected from the group consisting of —CH2—, —CH— and —O—; Y is selected from the group consisting of —CH2—, —CH— and a bond with the proviso that, when X is —O—, Y may not be a bond; Z is selected from the group consisting of —CH2— and —CH—; m is 0, 1 or 2; and n is 0, 1 or 2; and to pharmaceutically-acceptable acid addition salts of such compounds. The invention relates also to processes for preparing such compounds, compositions comprising such a compound or a pharmaceutically-acceptable acid addition salt thereof, and a method of treating a disease or disorder in a patient comprising administering such a compound, or pharmaceutically-acceptable acid addition salt thereof, to a patient in need of such treatment.
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