The United States of America; as represented by the Secretary; Department of Health and Human Services
发明人:
STEVENS, David Michael,STERN, Stephan Timothy,MCNEIL, Scott,DOBROVOLSKAIA, Marina A.
申请号：
AU2018350825
公开号：
AU2018350825A1
申请日:
2018.10.15
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
The present invention is directed to a polymer platform comprising poly(L-lysine succinylated) which specifically targets scavenger receptor A1. This platform may be used to conjugate different types of drugs to the polymer for treatment of specific diseases or conditions in a patient. The resulting conjugates display moderate stability or controlled drug release of about 3-80 hours in plasma, and allow delivery and release of drugs and other therapeutic moieties to tissues/cells that express scavenger receptor A1 in a controlled manner.
