BOEHRINGER INGELHEIM VETMEDICA S.A. DE C.V.;BOEHRINGER INGELHEIM VETMEDICA GMBH
发明人:
REALPE-QUINTERO MAURICIO ALBERTO,STADLER KONRAD,VAUGHN ERIC MARTIN,LEON KEMPIS MARIA DEL ROCIO,GONZALES-HERNANDEZ PAULINO CARLOS
申请号：
ARP110103916
公开号：
AR083533A1
申请日:
2011.10.21
申请国别(地区):
AR
年份:
2013
代理人:
摘要：
In addition, it also provides a nucleic acid molecule to encode H5 protein of influenza virus, which is a carrier including nucleic acid. Require 1: H5 protein of influenza virus, which is characterized by (a) amino acid 113d, 126h, 145 (-),In amendments 156r, 160F, 167t and 181n, amendment 145 (-) means that the position of amino acid 145 of H15 is secreted, or (b) amino acids 87P, 145l, 172t, 201e, 206i, 208k, 254t, 341g and 421k, or (c) amino acids 145l, 172t and 254v, where the position number of protein amino acids refers to H5. The location of amino acids is an example of SEQ ID 1, O (d), where H5 proteins include or consist of at least 95% of the amino acid sequence,96% at leastPreferably at least 97%,Preferably at least 98%Preferably at least 99%Or, preferably, 100% of the homology matches any of the sequences listed in SEQ ID 2-40. 113. Claim 13: the vaccine is characterized by: (a) H5 protein conforming to any of the requirements of 1-10, nucleic acid molecule conforming to 11 or vector conforming to 12； and (b) vehicle and / or pre disinfectant acceptable on drugs. Requirement 24: treatment or prevention method for influenza virus infection, which is characterized by providing effective high protein treatment quantity according to requirements 1 to 10,For the object requiring such treatment, or for the object requiring such treatment, the method includes effectively managing the nucleic acid H5 according to the requirements of item 11, or the carrier for effectively managing the nucleic acid H5 according to the requirements of item 12, Or the method includes providing effective therapeutic vaccine to the person in need of treatment according to the requirements of item 13 or 14. In either method, the influenza infection is mainly caused by the avian influenza virus, Pigs or humans, or any combination or mixture.Se provee además una molécula de ácido nucleico que codifica la proteína H5 del virus de la gripe, vector que comprende dicho ácido nucleico.Reivi
