Ronald J Buckanovich;Andrea Facciabene;George Coukos
发明人:
Ronald J Buckanovich,George Coukos,Andrea Facciabene
申请号：
US12076759
公开号：
US09289426B2
申请日:
2008.03.21
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention provides methods of treating and enhancing efficacy of immunotherapy for a solid tumor in a subject, comprising the step of contacting the subject with a compound or composition that modulates the expression or activity of ETRB, ET-1, ICAM-1, or another protein found herein to play a role in homing of T cells to a solid tumor. The present invention also provides methods of prognosticating a solid tumor in a subject, comprising the step of measuring an expression level of a protein found herein to play a role in homing of T cells to a solid tumor, or a nucleotide molecule encoding same.
