ETTINGER, CATHERINE,KARNELL, JODI,DAMSCHRODER, MELISSA,CHOWDHURY, PARTHA,XIAO, XIAODONG,TSUI, PING,VARKEY, REENA,DRABIC, STACEY,CARTER, LAURA,HERBST, RONALD,DU, QUN,NAIMAN, BRIAN MICHAEL
申请号：
CA2948275
公开号：
CA2948275A1
申请日:
2015.04.07
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
This disclosure provides IL-21 binding molecules, e.g., anti-IL-21 antibodies and antigen-binding fragments thereof. In certain aspects the anti-IL-21 antibodies and fragments thereof can be hybridoma-derived murine monoclonal antibodies, and humanized versions thereof. In certain aspects the binding molecules, e.g., anti-IL-21 antibodies and antigen-binding fragments thereof provided herein inhibit, suppress, or antagonize IL-21 activity. In addition, this disclosure provides compositions and methods for diagnosing and treating diseases or disorders, e.g., inflammatory, immune-mediated, or autoimmune diseases or disorders associated with IL-21 -mediated signal transduction. In a particular embodiment, the disclosure provides methods for treating or preventing Graft-versus-host disease (GVHD) using IL-21 binding molecules, e.g., anti-IL-21 antibodies and antigen-binding fragments thereof.
