A lead for nerve modulation comprises an elongated body which includes a proximal end, a distal portion having a distal end, and an intermediate portion disposed between the proximal end and the distal portion. The distal portion includes a distal portion anchoring mechanism to anchor the distal portion to a first biological cavity of a patient. The intermediate portion includes an intermediate portion anchoring mechanism to anchor the intermediate portion to a second biological cavity of the patient. The intermediate portion anchoring mechanism is larger in lateral dimension than and is spaced from the distal portion anchoring mechanism. The distal portion and/or the intermediate portion includes a plurality of modulation electrodes. The distal portion anchoring mechanism and/or the intermediate portion anchoring mechanism is configured to position the modulation electrodes to contact tissue of the patient at multiple locations.
