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TECHNOLOGIE D'ACTIVATION EFFICACE DE CELLULES NKT
专利权人:
Riken;Ambicion Co., Ltd.
发明人:
TANIGUCHI, Masaru,SHIGEURA, Tomokuni,AIHARA, Minako,HANADA, Keigo
申请号:
EP17789318
公开号:
EP3453755A4
申请日:
2017.04.14
申请国别(地区):
EP
年份:
2020
代理人:
摘要:
The present invention relates to a method for producing en NKT cell ligand-pulsed human CD14 positive cell that activates NKT cells and strongly induces proliferation, IFN-³ production, and/or cytotoxic activity of NKT cells. More specifically, the method is characterized in that the isolated CD14 positive cell is cultured in a medium containing an NKT cell ligand and GM-CSF and substantially free of IL-4. In addition, the present invention relates to a method for producing an NKT cell ligand-pulsed human CD14 positive cell line and, specifically, the method is characterized in that the isolated CD14 positive cell is cultured in a medium containing an NKT cell ligand and substantially free of GM-CSF and IL-4. The present invention also relates to a cell preparation containing an NKT cell ligand-pulsed human CD14 positive cell or an NKT cell ligand-pulsed human CD14 positive cell line and pharmaceutical use thereof.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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