The present invention relates to treatment and/or prevention of one or more metabolicdisorders utilizing fatostatin A and/or a derivative and/or analog thereof.In other aspects, the compound for treatment and/or prevention of one or moremetabolic disorders utilizes an A-B-C tripartite structure, wherein A, B, andC are identical or non-identical structures and are described in detail herein.In specific aspects, the metabolic disorder includes obesity or diabetes, forexample.