MCGILL UNIVERSITY;UNIVERSITAT POLITECNICA DE VALENCIA
发明人:
COLLINS, LOUIS,COUPE, PIERRICK,HERRERA, JOSE VICENTE MANJON
申请号：
CA2752370
公开号：
CA2752370A1
申请日:
2011.09.16
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
Applicants have discovered an innovative approach to robustly and accuratelydetectAlzheimer's disease (AD) and prodromal forms of AD based on the distinction ofspecific atrophic patterns of anatomical structures such as hippocampus (HC)andentorhinal cortex (EC) in regions of interest of an image. The discoveryallows toefficiently determine a pathological status and grading of pixels of interestwhencompared (weighed) to images from a reference library having pre-definedstates. Thediscovery simultaneously performs segmentation and grading of structures toefficientlycapture the anatomical alterations caused by AD. Based on a nonlocal patch-basedframework, the grading measure estimates the similarity of the patchsurrounding thevoxel under study with all the patches present in different trainingpopulations.
