The Penn State Research Foundation;Massachusetts Institute of Technology
发明人:
David A. Edwards,Robert S. Langer,Rita Vanbever,Jeffrey D. Mintzes,Jue Wang,Donghao Chen
申请号：
US14578598
公开号：
US20150342878A1
申请日:
2014.12.22
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a therapeutic, prophylactic or diagnostic agent or any combination thereof in association with a charged lipid, wherein the charged lipid has an overall net charge which is opposite to that of the agent upon association with the agent. Release of the agent from the administered particles occurs in a sustained fashion.
