A cleaning device, system and method for use with an ETT or tracheostomy ventilation tube (60), a ventilator machine (900), a source(s) (602) of fluid (for example, pressurized or unpressurized) and a source(s) of suctioning (603) is disclosed. In some embodiments, the cleaning device is useful for cleaning an inner surface of the ventilation tube (60) and/or for preventing or hindering the accumulation of biofilm thereon. In some embodiments, it is possible to clean biofilm or any other material on the inner surface (201) by delivering fluid into an interior of the ventilation tube, wiping the tube interior with a width- expanded wiping element (e.g. an inflated balloon) by longitudinal motion of the wiping element, and suctioning material out of the ventilation tube ventilation tube.
