Compositions for improving bone health, joint health, or both in an individual in need thereof are provided, along with methods of using the compositions. Generally, the compositions include a combination of Curcumin and Vitamin K2. The compositions may also include a protein, a carbohydrate, and a fat. The compositions and methods may be particularly useful in the treatment or prevention of osteoarthritis, rheumatoid arthritis, systemic lupus erythematosus, osteopenia, and osteoporosis.