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Pirimidil ciclopentanos Hydroxylated and Methoxylated as inhibitors of protein kinase AK, their uses, compositions, kits and dosage forms
专利权人:
ARRAY BIOPHARMA INC.
发明人:
申请号:
ARP130104510
公开号:
AR093810A2
申请日:
2013.12.05
申请国别(地区):
AR
年份:
2015
代理人:
摘要:
A compound with formula (1),Or a solved counterpart, a solved diagonal or salt, where R1 is h, me, et, vinio, cf832323,CHF o CH F R es H o Me R es H Me Et o CFA select (2) from the formula.(3) And (4),A is the formula (5);m. Both N and P are 0 or all 1; G is phenyl, which can be replaced by one to four r8313 or one 5-6 heteromorphic member, but can be replaced by a halogen; r8310 and r8311son are independent h, oc832323;(Cicloalquil C) - (CH)(Cicloalquil C) - (CH CH)V- (CH₂) ₀₋₁ where V is a 5-6 membered heteroaryl, W- (CH₂) ₁₋₂ where W is phenyl optionally substituted with F, Cl, Br, I, OMe, CF₃ or Me, C₃₋₆ cycloalkyl optionally substituted with C₁₋₃ or O alkyl (C₁₋₃ alkyl),hidroxi- (cicloalquilo C)Fluorine - (cycloquilo c83231;The heterocycle of CH (CH 832323) ch (OH) fenilo, 4-6 member, was replaced by F, oh, pitch c8321c833183323;ciclopropilmetilo o C (3DO) (alquilo C)or C₁₋₆ alkyl optionally substituted with one or more groups independently selected from OH, oxo, O (C₁₋₆ alkyl),CN F NHNH (No. c83231 / 832626)N (alquil C)cyclopropyl, phenyl, imidazolyl, piperidinyl, pyrrolidinyl, morpholinyl, tetrahydrofuranyl, oxetanyl or tetrahydropyranyl, or R⁶ and R⁷ together with the nitrogen to which they are attached form an optionally substituted 4-7 membered heterocyclic ring with one or more groups selected from independent way of OH, halogen, oxo, CF₃,CH₂CF₃,CH₂CH₂OH, O (C₁₋₃ alkyl),C (3DO) CHNH.8322;NHMe N (Me)S (O) CHcyclopropylmethyl and C₁₋₃ alkyl;e. R74919 and r7495son h, or r74919 es h, r7495y and r8310a, together with the atoms to which they are attached, form a 5-6 member heteromorphic ring with one or two nitrogen atoms in the ring; r758080 and r7496son h or me, or r758080 and r74966, together with the atoms to which they are attached, form a ring; r831222 h, me, R830 and r8310; a. A 5-6-member heterocyclic ring is formed with atoms. There are one or two nitrogen atoms in the ring. Each r8313 is an independent halogen, tar c83218331;C₃₋₆ cycloalkyl,O- (alqui
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