Pharmaceutical compositions are provided which include a microRNA pool capable of promoting, stimulating or increasing neuronal differentiation, as well as methods for treating, ameliorating and/or preventing depression or diseases where damage to nervous tissue occurs, such as neurological diseases, by means of such microRNA pool.L'invention concerne une composition pharmaceutique comprenant le pool de micro-ARN et un support et/ou diluant et/ou excipient pharmaceutiquement acceptable. L'invention concerne également l'utilisation de la composition pharmaceutique de l'invention en tant que médicament, en particulier pour une utilisation en tant que médicament approprié pour favoriser, stimuler ou augmenter la différenciation neuronale.