Provided are compositions comprising a reverse thermosensitive polymer, an immune response modifier (IRM), and ethanol. In certain aspects, the reverse thermosensitive polymer is polyoxamer 407 or PLGA-PEG-PLGA. The IRM can be a Toll-like receptor (TLR) agonist, in particular, a TLR7, TLR8, or TLR7/8 agonist.提供了包含反向熱敏聚合物、免疫應答調節劑(IRM)、以及乙醇之組成物。在某些方面,該反向熱敏聚合物係泊洛沙姆407或PLGA-PEG-PLGA。該IRM可以是Toll樣受體(TLR)激動劑,具體地是TLR7、TLR8、或TLR7/8激動劑。