INC.;INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE AS CR, V.V.I.;GILEAD SCIENCES, INC.;GILEAD SCIENCES
发明人:
RICHARD L. MACKMAN,MILAN DEJMEK,ONDRJ BASZCZYSKI,YUNFENG ERIC HU,ERIC LANSDON,PETR IMON,PETR JANSA
申请号：
ARP150104262
公开号：
AR103252A1
申请日:
2015.12.22
申请国别(地区):
AR
年份:
2017
代理人:
摘要：
This document describes the formulas (1) containing these compounds and the compounds, compositions and formulas of Tao Qiangji and its pharmaceutical salts, as well as the methods of using and preparing these compounds. 1. Claim 1: a formula compound (1),Q is the rest of the formula (2) or (3)；X1，X2，X3 is an independent n or C (R1),Yes, up to 2x1,X2，X3 is n, R1 is h, CN, or7491,-C (O) ORhalogen, C₁₋₆-alkyl,cycloalkyl C₃₋₁₀,O heterosexual c83218c31832626；where each C₁₋₆ alkyl,cycloalkyl C₃₋₁₀,and C₁₋₆ heteroalkyl is optionally substituted with 2, 3, 4, or 5 R¹² Groups,They may be the same or different, R2 es-h, CN, or74919,-No. 7491； No. 74955；-C (O) ORhalogen, C₁₋₆-alkyl,cycloalkyl C₃₋₁₀,O heterosexual c83218c31832626；where each C₁₋₆ alkyl,C8323218c832083208c833218c83321c8332626c8326r2 or 5 R2 substitutes；They may be the same or different； R3 ° es-h, or7491；-7491，-No. 7491； No. 74955；-NHC (O) NR R1. Lease land No. c833218331 and 832626；cycloalkyl C₃₋₁₀,O heterosexual c83218c31832626；where each C₁₋₆ alkyl,cycloalkyl C₃₋₁₀,and C₁₋₆ heteroalkyl is optionally substituted with 1, 2, 3, 4, or 5 R¹² Groups,R8308es-h, or74919；Halogen, n ° 832222,-CN - No. 7491； r7495；-NHC (O) NR R-OC (O) NR R-CH C (O) NR R1. Lease land No. c833218331 and 832626；cycloalkyl C₃₋₁₀,O heterosexual c83218c31832626；where each C₁₋₆ alkyl,cycloalkyl C₃₋₁₀,and C₁₋₆ heteroalkyl is optionally substituted with 1, 2, 3, 4, or 5 R¹² Groups,R8309es-h, or74919；Halogen, n ° 832222,-CN - No. 7491； r7495；-NHC (O) NR R-OC (O) NR R-CH C (O) NR R1. Lease land No. c833218331 and 832626；cycloalkyl C₃₋₁₀,O heterosexual c83218c31832626；where each C₁₋₆ alkyl,cycloalkyl C₃₋₁₀,and C₁₋₆ heteroalkyl is optionally substituted with 1, 2, 3, 4, or 5 R¹² Groups,R8310es-h-or74919；Halogen, n ° 832222,-CN - No. 7491； r7495；-NHC (O) NR R-OC (O) NR R-CH C (O) NR R1. Lease land No. c833218331 and 832626；cycloalkyl C₃₋₁₀,or C₁₋₃ heteroalkyl,where each C₁₋₆ alkyl,C8323218c832083208c833218c83321c8332626c8326r2 or 5 R2 substitutes；tha
