TRIPP, MATTHEW L.,DAHLBERG, CLINTON J.,BABISH, JOHN G.,KAADIGE, MOHAN,GAO, WEI
申请号：
CA2996627
公开号：
CA2996627A1
申请日:
2016.08.29
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
Disclosed herein are compositions and methods for acutely raising nitric oxide levels in a subject. In one example, the composition can include, an effective amount of a NOS dependent source of nitric oxide； an effective amount of a NOS independent source of nitric oxide； and an effective amount of a myeloperoxidase inhibitor； wherein the composition acutely raises nitric oxide levels in a subject above a level provided by the available sources of nitric oxide in the subject prior to administration of the composition. Further presented is a method of treating a subject for a condition or disorder that is response to nitric oxide therapy, including: acutely raising nitric oxide levels in a subject by simultaneously increasing biosynthesis of nitric oxide, increasing nitrate/nitrite levels, and inhibiting meyloperoxidase activity.
