The present disclosure relates to proteins including PD-L1 binding affimer polypeptide sequences, gene expression constructs encoded those proteins, cells expressing those proteins, and pharmaceutical preparations of those proteins, gene expression constructs and cells and use in the treatment of various human conditions including cancer.本發明係關於包括結合PD-L1之親和體多肽序列之蛋白質、編碼此等蛋白質之基因表現構築體、表現此等蛋白質之細胞及此等蛋白質、基因表現構築體及細胞之醫藥製劑以及在治療各種人類病狀,包括癌症中之用途。