TIMIRYASOVA TATYANA,YU YONG A.,ZHANG QIAN,SZALAY ALADAR A
申请号：
IN275/MUMNP/2010
公开号：
IN261088B
申请日:
2010.02.10
申请国别(地区):
IN
年份:
2014
代理人:
摘要：
Therapeutic methods and microorganisms therefore are provided. The microorganisms are designed to accumulate in immunoprivileged tissues and ceils, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. The microorganisms also are designed or modified to result in leaky cell membranes of cells in which they accumulate, resulting in production of antibodies reactive against proteins and other cellular products and also permitting exploitation of proferating tissues, particularly tumors, to produce selected proteins and other products.- Methods for making tumor specific antibodies and also methods of making gene products encoded by the microorganism as well as antibodies reactive therewith are provided.
