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INFLUENZA VACCINE WITH IMPROVED PRESEVATION AND STABILITY PROPERTIES COMPRISING A HYDROPHOBIC AMINO ACID, ARGININE AND AN ACID ADDITION SALT
专利权人:
OTSUKA PHARMACEUTICAL CO.; LTD.
发明人:
YAMASHITA, CHIKAMASA
申请号:
NZ57939508
公开号:
NZ579395A
申请日:
2008.03.07
申请国别(地区):
NZ
年份:
2012
代理人:
摘要:
Disclosed is a lyophilized preparation improved in the stability of an influenza vaccine contained therein. A lyophilized preparation remarkably improved in the stability of an influenza vaccine contained therein can be prepared by lyophilizing an aqueous solution satisfying the following requirements (A) to (C): (A) the aqueous solution contains (i) an influenza vaccine, (ii) a hydrophobic amino acid, and (iii) arginine and an acid addition salt thereof (B) the component (iii) is contained in an amount of 20 to 85% by weight relative to the total amount of the lyophilized preparation and (C) the pH value of the aqueous solution aqueous solution is adjusted to pH 8 to 10 by controlling the ratio between arginine and the acid addition salt thereof which constitute the component (iii).
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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