PROBLEM TO BE SOLVED: To provide a method of treating a chronic respiratory disorder or other chronic complement-mediated disorder.SOLUTION: The method comprises administering multiple doses of a complement inhibitor to the subject according to a dosing schedule in which successive doses are administered on average either (i) at least 2 weeks after the plasma concentration of the complement inhibitor decreases to no more than 20% of the maximum plasma concentration that was reached after the previous dose, (ii) at least 2 weeks after plasma complement activation capacity has returned to at least 50% of the baseline after the previous dose, (iii) at intervals equal to at least 2 times the terminal plasma half-life of the complement inhibitor, or (iv) at intervals of at least 3 weeks.SELECTED DRAWING: None【課題】慢性呼吸器障害又はその他の慢性補体介在性障害を治療する方法。【解決手段】補体阻害剤の複数回投与を、平均で（i）前記補体阻害剤の血漿中濃度が、前回の投与後に達した最高血漿中濃度の２０％以下に減少して少なくとも２週間後に、（ii）前回の投与後に血漿補体活性化能がベースラインの少なくとも５０％まで回復して少なくとも２週間後に、（iii）前記補体阻害剤の終末血漿中半減期の少なくとも２倍に等しい間隔で、又は（iv）少なくとも３週間の間隔で次の投与を実施する投与スケジュールに従って、前記対象に実施する方法。【選択図】なし
