A system and method includes data representing a sequence of X-ray images of a portion of patient anatomy acquired over a time interval and signal data representing electrical activity of the heart of the patient over the time interval, determination of a score value for each image of said sequence of X-ray images, selection of a set of images from said sequence of X-ray images based on the determined score values, the set of images excluding one or more images of said sequence of X-ray images, and generation of an averaged image from said set of images.
