Haiqing Yuan,John E. Donello,Richard L. Beard,Tien T. Duong,Xiaoxia Liu
申请号:
BRPI0821977
公开号:
BRPI0821977A2
申请日:
2008.07.10
申请国别(地区):
BR
年份:
2019
代理人:
摘要:
The invention provides compounds represented by the formula I, each of which compounds may have sphingosine-1-phosphate receptor agonist and/or antagonist biological activity: and wherein the variables Y, R<;SUP>;4<;/SUP>;, n, o, A, A<;SUP>;1<;/SUP>;, A<;SUP>;2<;/SUP>;, X, Z, R<;SUP>;1<;/SUP>;, R<;SUP>;3<;/SUP>;, R<;SUP>;2<;/SUP>;, p, q and r are as defined in the specification. These compounds are useful for treating a disease or condition selected from the group consisting of glaucoma, dry eye, angiogenesis, cardiovascular conditions and diseases, and wound healing