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DÉRIVÉ DE 17BÊTA-CYANO-18A-HOMO-19-NOR-ANDROST-4-ÈNE, SON UTILISATION, ET MÉDICAMENT CONTENANT CE DÉRIVÉ
专利权人:
BAYER INTELLECTUAL PROPERTY GMBH
发明人:
KUHNKE, JOACHIM,HUEBNER, JAN,BOHLMANN, ROLF,FRENZEL, THOMAS,KLAR, ULRICH,MENGES, FREDERIK,RING, SVEN,BORDEN, STEFFEN,MUHN, HANS-PETER,PRELLE, KATJA
申请号:
EP08758989.1
公开号:
EP2178899B1
申请日:
2008.06.04
申请国别(地区):
EP
年份:
2012
代理人:
摘要:
The 17beta-cyano-18a-homo-19-nor-androst-4-ene derivatives of the present invention possess gestagenic activity. They have the general chemical formula 1, in which Z is selected from the group comprising O, two hydrogen atoms, NOR and NNHSO2R, in which R is hydrogen or C1-C4-alkyl, R4 is hydrogen or halogen, furthermore either: R6a, R6b together form methylene or 1,2-ethanediyl or R6a is hydrogen and R6b is selected from the group comprising hydrogen, methyl and hydroxymethylene, and R7 is selected from the group comprising hydrogen, C1-C4-alkyl, C2-C3-alkenyl and cyclopropyl, or: R6a is hydrogen and R6b and R7 either together form methylene or are omitted with formation of a double bond between C6 and C7, R9, R10 are hydrogen or are omitted with formation of a double bond between C9 and C10, R15, R16 are hydrogen or together form methylene, R17 is selected from the group comprising hydrogen, C1-C4-alkyl and allyl, at least one of the substituents R4, R6a, R6b, R7, R15, R16 and R17 not being hydrogen or R6b and R7 being omitted with formation of a double bond between C6 and C7 or being omitted with formation of a double bond between C1 and C2, and moreover comprise their solvates, hydrates, stereoisomers, diastereomers, enantiomers and salts.
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