LIPID FORMULATED COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF HUMAN KINESIN FAMILY MEMBER 11 (Eg5) AND VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) GENES
594995 LIPID FORMULATED COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF Eg5 AND VEGF GENES Provided is a composition comprising a nucleic acid lipid particle comprising a first double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a human kinesin family member 11 (Eg5/KSP) gene in a cell and a second dsRNA for inhibiting expression of a human VEGF in a cell, wherein the nucleic acid lipid particle comprises a lipid formulation comprising (i) 45 mol % to 65 mol % of a cationic lipid, (ii) 5 mol % to about 10 mol %, of a non-cationic lipid, (iii) 25 mol % to 40 mol % of a sterol, and 0.5 mol % to 5 mol % of a PEG or PEG-modified lipid, and wherein the cationic lipid comprises MC3 ((6Z,9Z,28Z,31Z)-heptatriaconta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate).
