Oral solid pharmaceutical composition containing a proton pump inhibitor, oral solid pharmaceutical preparation containing the same, and method for producing the same
The present invention comprises a proton pump inhibitor or a pharmaceutically acceptable salt thereof； and a binding solution containing a basic additive； the content of the basic additive is the proton pump inhibitor or a pharmacy thereof. The present invention relates to an oral solid preparation composition, which comprises 2 to 13 parts by weight based on 100 parts by weight of an acceptable salt, an oral solid preparation thereof, and a method for producing the same. According to the present invention, it is possible to provide an oral solid preparation having excellent stability against water and low pH by significantly reducing the production of soft substances. [Selection diagram] Fig. 1本発明は、プロトンポンプ阻害剤又はそれの薬学的に許容可能な塩；及び塩基性添加剤を含む結合液；を含み、前記塩基性添加剤の含量は、前記プロトンポンプ阻害剤又はそれの薬学的に許容可能な塩１００重量部を基準で２～１３重量部であることを特徴とする経口用固形製剤組成物及びそれの経口用固形製剤及びその製造方法に関する。本発明によると、柔軟物質の生成が顕著に減少されて水分及び低いｐＨに対する安定性に優れた経口用固形製剤を提供することができる。【選択図】図１
