ZANGEMEISTER-WITTKE, UWE,DI PAOLO, CLAUDIO,TSCHUDI, DOMINIQUE CHRISTINE,GLOVER, NICHOLAS RONALD,FITSIALOS, DIMITRI PETER
申请号：
CA2524124
公开号：
CA2524124C
申请日:
2004.04.30
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
The present invention relates to methods for preventing or treating head andneck squamous cell cancer and bladder cancer using an immunotoxin comprising(a) a ligand that binds to a protein on the cancer cell attached to； (b) atoxin that is cytotoxic to the cancer cell. In a specific embodiment, theinvention is directed to the prevention or treatment of head and neck squamouscell cancer or bladder cancer using VB4-845, which is a recombinantimmunotoxin comprising a humanized, MOC31-derived, single-chain antibodyfragment that is fused to a truncated form of Pseudomonas exotoxin A. Alsoencompassed by the invention are combination therapy methods, including theuse of reduced dosages of chemotherapeutic agents, for the prevention ortreatment of cancer. Also encompassed by the invention are formulations andmethods for direct administration of the recombinant immunotoxin to thecarcinoma, for the prevention or treatment of cancer.
