STOKES, STEPHEN,FOLOPPE, NICOLAS,FIUMANA, ANDREA,DRYSDALE, MARTIN,BEDFORD, SIMON,WEBB, PAUL
申请号：
CA2712959
公开号：
CA2712959C
申请日:
2009.01.20
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
Compounds of formula (I) have checkpoint kinase 1 (CHK1 ) inhibitory activity:wherein R1, R2, R5 and R6 are inde-pendently selected from hydrogen, hydroxy,methyl, trifluoromethyl, hydroxymethyl, methoxy, trifluoromethoxy, methylaminoanddimethylamino； R3, and R4 are independently selected from hydrogen, hydroxy,C1-C3 alkyl, fluoro-(C1-C3)-alkyl, hydroxy-(C1C3)--alkyl, C1-C3 alkoxy, fluoro-(C1-C3)-alkoxy, hydroxy-(C1-C3)-alkoxy, -N(R11)-R12, -AIk-N(R11)-R12, -0-AIk-N(R11)-R12, -C(=O)OH,carboxy-(C1-C3)-alkyl, or -C(=O)-NH-R13； AIk is a straight or branched chaindivalent C1-C6 alkylene radical； R7 and R8 are in-dependently selected fromhydrogen, hydroxy, or C1-C3 alkoxy； X is a straight chain divalent C1-C3alkylene radical, optionallysubstituted on one or more carbons by R9 and/or R10； W is selected from -C(=O)-N(-R16)- or -N(-R17)-C(=O)-； Y is hydrogen, C1-C3alkyl, C1-C3 alkoxy, or halo； and Q is selected from optionally substitutedphenyl, optionally substituted cyclohexyl, or an optionallysubstituted 6-membered monocyclic heteroaryl ring.
