Provided herein are antibodies that specifically bind to GPRC5D. Also described are related polynucleotides capable of encoding the provided GPRC5D-specific antibodies or antigen-binding fragments, cells expressing the provided antibodies or antigen-binding fragments, as well as associated vectors and detectably labeled antibodies or antigen-binding fragments. In addition, methods of using the provided antibodies are described. For example, the provided antibodies may be used to diagnose, treat, or monitor GPRC5D-expressing cancer progression, regression, or stability； to determine whether or not a patient should be treated for cancer； or to determine whether or not a subject is afflicted with GPRC5D-expressing cancer and thus may be amenable to treatment with a GPRC5D-specific anti-cancer therapeutic, such as the multispecific antibodies against GPRC5D and CD3 described herein.本文提供特異性結合至GPRC5D的抗體。亦描述能夠編碼所提供之GPRC5D特異性抗體或抗原結合片段的相關多核苷酸、表現所提供之抗體或抗原結合片段的細胞、以及相關聯之載體及經可偵測標示之抗體或抗原結合片段。此外，描述使用所提供抗體之方法。舉例而言，所提供之抗體可用來診斷、治療、或監測GPRC5D表現性癌症之進展、消退、或穩定；用來判定病患是否應該進行癌症治療；或者用來判定對象是否罹患GPRC5D表現性癌症，並因而可適合用GPRC5D特異性抗癌症治療劑諸如本文中所述之針對GPRC5D及CD3的多特異性抗體來進行治療。
