The synthetic method of the pure CIS- imidazolinium compounds used for drug is generated for enantioselectivity

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专利权人:

UNITY BIOTECHNOLOGY; INC.

发明人:

CHEN, BING,VON GELDERN, THOMAS W.,BACKES, BRADLEY

申请号：

CA3033850

公开号：

CA3033850A1

申请日:

2017.06.16

申请国别(地区):

CA

年份:

2018

代理人:

摘要：

The invention discloses a kind of methods of enantioselective synthesis for cis-imidazolines and in relation to structure by chiral resolution. A pair of of chiral acid is from a kind of racemic mixture by selective freezing for separating the enantiomer precursor of cis-imidazolines. Two enantiomers can be cyclized into required cis--imidazoline by complementary pathway. Compound can synthesize an enantiomeric excess high as 99% and can be used for treating cancer, kill senile cell, or processing aging-associated condition.

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中国工程科技知识中心

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