A skin treatment system (1) is provided comprising a treatment device (10) to treat a treatment region (TR) of a mammal body (B) by physically acting upon the body in said treatment region. The skin treatment system further comprises a camera (20) to capture at least one image of skin of the mammal body, said image having an imaging region (IR), and to provide captured image data (Id) representative of the at least one captured image. The imaging region (IR) has a predefined spatial relationship with the treatment region. The skin treatment system (1) further comprises a storage facility (30) for storing reference image data (Ir) indicative of a reference image of the skin of the mammal body (B). The skin treatment system (1) further comprises an orientation estimation facility (40) to determine which part of the reference image corresponds to the at least one captured image, using the captured image data (Id) and the reference image data (Ir), and to derive from a predetermined orientation of said corresponding part with respect to the reference image an orientation indication (Io) indicative of an orientation of the treatment device with respect to the body (B). A corresponding method of determining an orientation of a skin treatment device with respect to a mammal body is also provided. Furthermore, a skin analysis system and a corresponding method of analyzing skin are provided to render reference image data for use in the skin treatment system (1).
