A two-piece, sanitary, safe and humane mousetrap comprising an entrance device and a container, wherein the entrance device comprises a tunnel, a one-way door, a mousetrap support piece, a fastening mechanism, and a door locking mechanism, is disclosed. Specifically, the mousetrap is formed by inserting the container to the entrance device from the back of the tunnel all the way to the one-way door. Preferably the one-way door comprises a pivotal wire door with a push-and-lock mechanism or comprises a gate with a touch-and-drop mechanism. The preferred entrance device is able to fit a common bottle. When the entrance device contains a flat rim fitted around the tunnel, the entrance device is capable of fitting containers of various sizes and shapes during repeated uses.