This invention provides a method of treating a subject afflicted with active lupus arthritis comprising periodically administering to the subject an amount of laqumimod or pharmaceutically acceptable salt thereof effective to treat the subject. This invention also provides laqumimod or pharmaceutically acceptable salt thereof for use in treating a subject afflicted with active lupus arthritis This invention further provides a pharmaceutical composition comprising an amount of laqumimod or pharmaceutically acceptable salt thereof for use in treating a subject afflicted with lupus arthritis.