DERIVES DU PYRIDONE DESTINES A LA MODULATION DU SYSTEME DE KINASE PROTEINIQUE ACTIVE PAR LE STRESS

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专利权人:

INC.;INTERMUNE

发明人:

申请号：

EP06759440.8

公开号：

EP1928454B1

申请日:

2006.05.09

申请国别(地区):

EP

年份:

2014

代理人:

摘要：

Disclosed are methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of at least one p38 MAPK； and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the at least one p38 MAPK by the compound. Also disclosed are derivatives of pirfenidone. These derivatives can modulate a stress activated protein kinase (SAPK) system.

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中国工程科技知识中心

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