The present invention discloses a pharmaceutical composition and its application, wherein the pharmaceutical composition comprises one mitochondria of an effective amount and at least one pharmaceutically acceptable carrier. By medicating the pharmaceutical composition to a human body, the mitochondria is sent into lung cells that were damaged or faced with oxidative stress, thereby achieving the effect of treatment or amelioration of lung injury or diseases related to lung injury. Preferably, the pharmaceutical composition may include an effective dose of Melatonin.本發明係揭露一種新穎醫藥組合物及其用途,其中,該新穎醫藥組合物係至少包含有一有效量之粒線體及至少一藥學上可接受之載體。藉由投予該新穎醫藥組合物至一個體,將粒線體送入受損或面臨氧化壓力之肺部細胞內,能夠達到治療或改善肺部損傷或是與肺部損傷相關疾病之功效。
